Given that total cDCs have been reported to exacerbate GvHD, whereas CD8α+ cDC1s are highly effective suppressors of GvHD, we evaluated the ratio of CD8α+cDC1 to SIRPα+cDC2 in each mouse conditioned with BEN+TBI or CY+TBI. This evidence concerns the gene SIRPA and graft versus host disease.