ISG15 and cystic fibrosis: The key hub genes regulating the CF AEC response subnetwork included IRF1, ISG15, STAT1, STAT3, HSAP1B, CASP8, TBK1, IKBKE, TRAF2, and CASP8. The key hub genes of both CF and non-CF subnetworks are represented by key regulators related to the innate immune system and cytokine signaling.