The changes of genes involved in nucleotide biosynthesis pathway pyrimidine catabolism were observed, including NT5C3A, DPYD, TYMP, and NT5E. Changes in gene expression of caspases (CASP1, 4, 8, 10), which provide pivotal links in cell regulatory networks controlling inflammation and cell death, were also observed in both CF and non-CF AEC post-RV infection. Here, NT5C3A is linked to cystic fibrosis.