Other common cytokine responses, such as interleukin 20 family signaling (Figure 4A, Table S6), was over-represented with upregulation of IL22RA1, STAT family (STAT1, 2, 3, and 5A), JAK family (JAK1, JAK2), and the negative regulator of IFN signaling SOCS3. Infection with RV has also significantly increased gene expression of chemokines such as CXCL10, CXCL11, CXCL3, CXCL16, CCL2, CCL5, and CCL20 in both CF and non-CF AECs. This evidence concerns the gene SOCS3 and infection.