Further, IFITM2 was significantly up-regulated and induced after activation of beta-catenin signaling in colorectal cancers (50), and it was also reported to promote gastric cancer growth and metastasis through the insulin-like growth factor (IGF1)/IGF1 receptor (IGF1R)/STAT3 signaling pathway (51). This evidence concerns the gene IFITM2 and colorectal cancer.