Our laboratory has reported that hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization, which promotes proliferation, migration, and invasion in vitro and in vivo of glioma cells by targeting telomere binding repeat 2 interacting protein (TERF2IP) through the STAT3 and NF-κB pathways (44). This evidence concerns the gene NFKB1 and central nervous system cancer.