Further, the importance of HSPA8 in IBV-Beaudette strain infection was also studied by binding blocking assay and infection inhibition assay after removal of HS with heparanase I. As shown in Figure 6B, when HS was removed, recombinant HSPA8 was able to block IBV Beaudette strain binding to Vero cells. The gene discussed is HSPA8; the disease is infection.