TBX21 and infection: Indeed, it has previously been reported that T-bet-deficient mice are unable to control bacterial replication following infection with intracellular pathogens, such as Salmonella enterica serovar typhimurium (Ravindran et al., 2005), Leishmania major (Szabo, 2002), Francisella tularensis (Melillo et al., 2014), or Mycobacterium avium and tuberculosis strains (Sullivan et al., 2005; Matsuyama et al., 2014).