RB1 and infection: ➢ Degrades Daxx ➢ Transactivation MIE gene ➢ Degrades Rb at the onset of lytic infection, promotes cell progression and inhibits apoptosis ➢ Binds to STING and impedes subsequent activation of TBK1 and IRF3, a method against innate immunity ➢ Circumvent surface MHC-I expression