A serials of preclinical researches of MMP inhibitors like CM352 (88, 166–168), and neuroprotectors such as NXY-059 (169, 170), NSP-116 (171), erythropoietin (172), valproic acid (173), memantine (174), curcumin (175), albumin (176), and tuftsin fragment 1-3 (177) have shed light on the treatment of HE. This evidence concerns the gene ALB and hereditary elliptocytosis.