We could not observe a correlation between age and CHI3L1 or the Glia score in CSF and serum of PMS patients (Spearman ρ < 0.3) and only for age and the Glia score in RRMS patients (Spearman ρ = 0.53 for CSF and 0.38 for serum, p = 0.0002 and 0.008, respectively). The gene discussed is CHI3L1; the disease is premenstrual tension.