Ding et al. (2008a, b) identified two voltage-gated K+ channels, Eag1 (KV10.1, KCNH1) and hERG1 (KV11.1, KCNH2), which are aberrantly expressed in ESCC and are correlated with poor prognosis (Ding et al., 2008a, b). This evidence concerns the gene KCNH1 and esophageal squamous cell carcinoma.