TLR4 and Sepsis: It is well established that physical exercise has the ability to reduce inflammatory responses, tissue damage, and mortality in cases of sepsis—a systemic inflammatory condition that unleashes response through toll-like receptors (TLRs), especially TLR-2 and TLR-4, proteins of a pathway that can be also modulated by physical exercise (De Araújo et al., 2012; Coelho et al., 2013; Hung et al., 2013; Sossdorf et al., 2013; Cavalcante et al., 2017).