Although the activation of JNK has been deeply implicated in apoptosis/necrosis induction in different types of cancer cells (Deng et al., 2018; Qiao et al., 2019), inhibition of JNK by SP600125 did not alter the induction of apoptosis/necrosis (Figure 8), suggesting little involvement of JNK activation. The gene discussed is MAPK8; the disease is cancer.