For example, Geniposide can simultaneously regulate the expression of FXR, PXR, NF-κB, Bax, and Bcl-2, and has a great effect on various liver diseases such as cholestasis and liver inflammation (Rong et al., 2017; Wang et al., 2017; Hu et al., 2018). This evidence concerns the gene NR1H4 and cholestasis.