Resveratrol has a therapeutic effect on ANIT induced cholestasis by regulating the FXR pathway, and it also has a very good improvement on non-FXR target genes, such as liver inflammatory factors TNFα, IL-6, and IL-1β, as well as oxidation factor COX-2 (Ding et al., 2018). Here, NR1H4 is linked to cholestasis.