In addition to the praeruptorin A and C mentioned above, which can improve cholestasis by activating CAR, studies have found some CAR natural product agonists, such as berberine (Zhang et al., 2016), Arecoline (Ling et al., 2014), artemisinin (Burk et al., 2005), and 6,7-dimethylesculetin(Huang et al., 2004), etc. (Figure 3), but these CAR agonists have not been proven effective for cholestatic liver disease. Here, NR1I3 is linked to cholestasis.