Our previous study found that ZWT mitigated membranous nephropathy through depressing NF-κB pathway and NLRP3 inflammasome (Liu et al., 2019).In addition, ZWT decreased proteinuria, alleviated kidney pathology and podocyte damage via blocking NF-κB pathway in IgAN rats model (Liu et al., 2018). The gene discussed is NFKB1; the disease is membranous glomerulonephritis.