DNER and cancer: BRD4, an epigenetic reader, is one of the most important BET proteins and plays an important role in angiogenesis and the development of inflammation-associated diseases, cardiovascular diseases, central nervous system disorders and cancers (Belkina and Denis, 2012; Shi et al., 2014; Padmanabhan et al., 2016; Tian et al., 2016; Wu et al., 2017; Liu et al., 2018; Tan et al., 2018; Tian et al., 2018; Tian et al., 2019a; Tian et al., 2019b; Zhao et al., 2019).