TH and Anxiety: Indeed, repeated administration of Bupleuri Radix (BR), a component of the KKT formula, significantly suppressed stress-induced upregulation of tyrosine hydroxylase in the locus coeruleus, which is the main noradrenergic center in the brain, thereby preventing anxiety behavior in the EPM (Lee et al., 2012) and suggesting possible long-term alterations in neurotransmitter systems by chronic KKT treatment.