Overall, our results point that the susceptibility of young/activated microglia to Bf-induced inflammatory response may associate to the damaging effects of hyperbilirubinemia during the neurodevelopment period and may be implicated in poorer outcomes of the prematurely born neonates, highlighting the need of immunoregulatory strategies against BIND in the sickest infants. The gene discussed is CFB; the disease is Hyperbilirubinemia.