As a curiosity, in obstructive jaundice, miR-21 and miR-125b, among others, were found upregulated in the mouse liver (Kanda et al., 2010) and the later associated with increased tau hyperphosphorylation (Banzhaf-Strathmann et al., 2014; Zhang et al., 2019). The gene discussed is MAPT; the disease is obstructive jaundice.