This is particularly fascinating because TSC is also characterized by altered mTORC2 pathway activity and mTORC2 is implicated in mediating behavioral and neurophysiological changes in mice having neuron PTEN deletion, which mimics the TSC-related disorders Cowden Syndrome and Lhermitte-Duclos disease (Chen et al., 2019). This evidence concerns the gene PTEN and tuberous sclerosis.