ADCYAP1R1 and Parkinson disease: Indeed, PACAP stimulates endozepine release from cultured astrocytes via a PAC1R/PKA pathway (Masmoudi et al., 2003) and intracerebroventricular injection of the endozepine octadecaneuropeptide (ODN) prevents the degeneration of dopaminergic neurons in an in vivo model of PD (Bahdoudi et al., 2018).