Indeed, PACAP stimulates endozepine release from cultured astrocytes via a PAC1R/PKA pathway (Masmoudi et al., 2003) and intracerebroventricular injection of the endozepine octadecaneuropeptide (ODN) prevents the degeneration of dopaminergic neurons in an in vivo model of PD (Bahdoudi et al., 2018). This evidence concerns the gene ADCYAP1 and Parkinson disease.