To analyze the effect of intravenous injection of PHF-tau proteins on amyloid plaque formation, we quantified by immunohistochemistry the load of amyloid plaques in non-injected or injected 5XFAD mice with antibodies to Aβ40 and to Aβ42 and with thioflavin staining (Figure 3). Here, MAPT is linked to amyloidosis.