DLG4 and vascular dementia: Fourth, zoledronate may reduce oxidative stress and apoptosis, analogous to etidronate that rescued spatial memory and upregulated long-term potentiation proteins, such as calcium/calmodulin-dependent protein kinase II (CaMKII), NMDAR 2B, and PSD95 in a model of vascular dementia (Li et al., 2017).