Interestingly, there is considerable experimental evidence to suggest abnormal IP3R1 function, a downstream signaling protein found within the PKCγ pathway, in the pathogenesis of many spinocerebellar ataxias and other neurodegenerative diseases including Huntington’s disease and Alzheimer’s disease (Tada et al., 2016; Prestori et al., 2019). This evidence concerns the gene PRKCG and cerebellar ataxia.