PRKCG and spinocerebellar ataxia type 14: Spinocerebellar ataxia type 14 is caused by mutation to of the PRKCG gene (Brkanac et al., 2002; Morita et al., 2006), which encodes the PKCγ isoform of the PKC subfamily (PKCγ) and is activated by binding with the secondary messenger DAG, in the presence of phosphatidylserine (Berridge and Irvine, 1984; Saito and Shirai, 2002).