Moreover, PD-L1 positivity was significantly more frequent in the presence (N1/N2/N3, 48.4%) than in the absence of lymph node metastasis (N0, 33.8%; p=0.005) and in SCC (64.2%) rather than in ADC patients (28.5%; p < 0.0001). This evidence concerns the gene CD274 and metastatic malignant neoplasm in the lymph nodes.