In the present study, low IGF-1 was an insignificant independent risk factor after adjustment for age because a negative correlation was observed between age and IGF-1 levels (r = −0.42, P < 0.01, S1 Fig) Other factors related to endocrine disorders were not identified as risk factors of osteosarcopenia development, with the exception of high HbA1c. The gene discussed is IGF1; the disease is endocrine system disorder.