Several studies reported that the level of NS1 was higher in patients with severe dengue (SD) [16, 17] and it appears to contribute to disease severity by inducing IL-10 production by monocytes [18], activating immune cells via toll-like receptor 4 [19] or disrupting the endothelial glycocalyx components leading to increased vascular permeability [20]. This evidence concerns the gene IL10 and dengue disease.