Increased expression of SFRP1, CCND1 and WNT 5A was related to the downregulation of PTCH1, JAG2, LRP5, WNT1, APC, CTNNB1, and CDH1. Interaction between these genes may lead to the non-canonical signalling of SFRP1 and result in cancer dissemination. The gene discussed is PTCH1; the disease is cancer.