We observed that PRMT1 depletion or treatments designed to prevent SAM or ATP accumulation in breast cancer cells made the cells more susceptible to IR-induced apoptosis both in vitro and in vivo (Fig. 5A,B), while PRMT1 overexpression protected MDA-MB-231 cells from apoptosis at high IR doses (Fig. 5C). This evidence concerns the gene PRMT1 and breast carcinoma.