This percentage is higher than the 10%-20% observed in most studies irrespective of the method of HPV-specific testing applied36, although it is lower than the 47% reported in an Italian study that considered a case to be p16INK4a positive if strong nuclear and cytoplasmic staining was present in > 50% of the tumour cells37. The gene discussed is CDKN2A; the disease is neoplasm.