In addition, endoplasmic reticulum (ER) targeting was described to result in JNKs activation resulting in apoptosis of prostate cancer cells (via Ca2+ release induced JNK activation followed by the cleavage of executioner caspases; or ER stress induced IRE-1/ASK1/JNK signaling followed by intrinsic apoptosis)51. This evidence concerns the gene MAP3K5 and Familial prostate cancer.