AKT1 and glioblastoma: Inhibition of Akt phosphorylation by Akt inhibitor IV sensitized glioblastoma cells to t-AUCB and strengthened t-AUCB in suppressing cell growth and inducing cell apoptosis, and inhibition of both p-Hsp27 and p-Akt could synergistically strengthen t-AUCB in suppressing cell growth44.