SCUBE3 and central nervous system cancer: Kaplan–Meier survival curves30 (http://kmplot.com/analysis/) showed that SCUBE3 was prognostic and favorable in some cases (esophageal adenocarcinoma, head–neck squamous cell carcinoma, lung adenocarcinoma, lung cancer, and kidney renal clear cell carcinoma) or unfavorable in others (bladder carcinoma, cervical squamous cell carcinoma, kidney renal papillary cell carcinoma, sarcoma, stomach adenocarcinoma, ovarian cancer, and gastric cancer) when considering the high expression group and low expression group in pan-cancer analysis (Fig. 7a), but this did not include information on gliomas.