Xenograft tumors generated from H1299 cells and H1299 stably overexpressing NIP30 4D, but not NIP30 4A, had strikingly reduced tumor volumes following treatment with cisplatin, doxorubicin, or 5-fluorouracil (Fig. 6c, d), suggesting that blockade of the REGγ pathway by its inhibitor, NIP30, dramatically increases anticancer sensitivity in p53-deficient tumor cells. Here, PSME3IP1 is linked to neoplasm.