MTOR and cancer: The mechanistic (mammalian) target of rapamycin complex (MTORC) is critical for sensing multiple variables related to metabolism,14 and thus, it has been recognized as a pivotal factor for controlling metabolite-dependent cell growth.15 Indeed, hyperactive MTOR signaling is frequently observed in cancer pathology.16,17 Many factors regulate MTOR activation in different physiological and pathological conditions, including but not limited to KLHL22, SAMTOR, and Sestrin2;16,18–21 however, the potential influences of MTOR on tumor vaccination have rarely been characterized.