At the end point of tumor growth experiments, Zfra significantly suppressed the expression of Hyal-2 and phosphorylation of WWOX at Y33 and Y61 (>90%), but no significant changes were observed for WWOX phosphorylation at S14 and Y287 in the spleen of the sacrificed mice (<5%; Figure 4C–E). The gene discussed is HYAL2; the disease is neoplasm.