Notably, Zfra4-10 or WWOX7-21 peptide induced the binding of endogenous WWOX with ERK, C1qBP, NF-κB, Iba1, p21, CD133, JNK1, COX2, Oct4, and GFAP in the spleen, brain, and/or lung, which correlates with cancer suppression. This evidence concerns the gene POU5F1 and cancer.