When mice received Zfra4-10 or WWOX7-21 peptide alone followed by 4T1 breast cancer inoculation, these mice developed endogenous complex formation of WWOX with many target proteins, including ERK, C1qBP, NF-κB, Iba1, p21, CD133, JNK1, COX2, Oct4, and GFAP in the spleen, brain, and lung. This evidence concerns the gene PROM1 and breast cancer.