Taken together, we determined the anticancer response of Zfra4-10 or WWOX7-21 peptide, which involves (1) induction of WWOX complex formation with selective target proteins in organs, and correlation with induction of cancer growth suppression; (2) de-phosphorylation of pY33- and pY61-WWOX, as it is needed for spleen Z cell activation and expansion to kill cancer cells; and (3) Zfra suppression of S14 phosphorylation of WWOX in the cancer lesions, as it is crucial for growth suppression. This evidence concerns the gene WWOX and cancer.