To further validate the Hyal-2/WWOX signaling in cancer suppression, BALB/c mice were pretreated with Hyal-2 IgG, medical grade hyaluronan (HAn), sonicated HA (HAson3 or HAson6 for sonication for three or six hours), and UV-irradiated HA (HAuv for four or eight hours), respectively, via tail vein injections once per day for three days. The gene discussed is HYAL2; the disease is cancer.