HYAL2 and cancer: Under similar experimental conditions, antiserum against WWOX at pY33 or pY287, along with Hyal-2 antiserum, reduced the BCC tumor growth in T/B-deficient NOD-SCID mice (30 to 50% reduction; Figure 3H–N), suggesting that Zfra inhibits WWOX phosphorylation at Tyr33, which is needed for suppressing cancer growth.