As PPAR are known to be key players in lipid and glucose homeostasis [126], it is plausible that phthalate involvement in metabolic disorders likely correlate to their binding to PPAR-α, γ, the latter associated to adipogenesis, and controlled by neuroendocrine pathways involved in the hypothalamic-pituitary-adrenal axis [127], but also to other receptors such as steroid hormone receptors, thyroid hormone receptors, retinoid X receptors, liver X receptors, and farnesoid X receptors [107]. This evidence concerns the gene PPARA and metabolic disease.