In a study by Lukassen et al. [98] RNA sequencing was used to analyze the expression of both ACE-2 and TMPRSS2 in lung tissue and single cells obtained from normal subsegmental bronchial branches and lung tissues that were resected from 16 patients with lung cancer (6 males and 10 females; mean age ~50 years) [98]. This evidence concerns the gene TMPRSS2 and lung carcinoma.