Due to the acute role of TMPRSS2 as a host cell factor for viral infections [27,28,92,158], serine protease inhibitors (Camostat, Nafamostat, and Leupeptin) have been implicated in the antiviral therapeutic strategy targeting TMPRSS2 with high antiviral activities [92,173,174]. Here, TMPRSS2 is linked to viral infectious disease.