TP53 and cholangiocarcinoma: Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is a derivative from chili peppers inhibited the migration of cholangiocarcinoma cells by downregulating metalloproteinase-9 expression [25] and promoting apoptosis by stimulated p53 and Bax expression in HCT116 human colon carcinomas [26].