Thus, the aMMP-8 ImplantSafe-ORALyzer kit detected peri-implantitis-affected sites more efficiently than aMMP-8 (IFMA), MMP-8/TIMP-1, PMN elastase, MPO, TIMP-1, actMMP-9 and proMMP-9 and BOP as illustrated by the ROC analysis in Figure 1 and Table 3. The gene discussed is TIMP1; the disease is Peri-Implantitis.