MCM3 and cancer: The acid adaptation-downregulated genes overlapping with genes downregulated in patient cancers, and for which high expression was associated with good prognosis (i.e., potential candidates for pro-tumorigenic effects of acid adaptation, Figure 6B, lower list) included AKAP5 and ZNF557, described above, as well as several DNA replication- and repair-related genes, including the genes encoding the DNA repair protein MMS22L, the DNA replication licensing factor MCM3, and the replication fork complex protein GINS2.