The acid adaptation-downregulated genes overlapping with genes downregulated in patient cancers, and for which high expression was associated with good prognosis (i.e., potential candidates for pro-tumorigenic effects of acid adaptation, Figure 6B, lower list) included AKAP5 and ZNF557, described above, as well as several DNA replication- and repair-related genes, including the genes encoding the DNA repair protein MMS22L, the DNA replication licensing factor MCM3, and the replication fork complex protein GINS2. This evidence concerns the gene ZNF557 and cancer.