TCF7L2 and type 2 diabetes mellitus: Variants of the gene encoding the brain-derived neurotrophic factor (BDNF) were found to show significant associations with energy and protein intake in Korean adults with type 2 diabetes [21]; furthermore, a study on the Canadian population examined the reactivity of transcription factor 7-like 2 (TCF7L2) to dietary fat intake, influencing insulin sensitivity and glucose tolerance [22].