S64315 (MIK665), which is derived from S63845, has similar chemical properties to inhibit MCL1, and is currently in clinical trials for AML (ClinicalTrials.gov NCT02992483; NCT02979366; https://clinicaltrials.gov/ct2/show/NCT02992483; https://clinicaltrials.gov/ct2/show/NCT02979366). The gene discussed is MCL1; the disease is acute myeloid leukemia.