CDH1 and breast carcinoma: In line with this observation, it has been reported that the transfer of the EVs from highly metastatic MDA-MB-231 breast cancer cells to non-malignant breast epithelial cells MCF-10A, induced an increased secretion of MMP-2 and MMP-9 from the recipient cells together with an EMT phenotype characterized by a reduced expression of the epithelial marker E-cadherin and an increased expression of several mesenchymal markers (e.g., SNAIL, TWIST, vimentin and N-cadherin) [31].