In line with these observations, other authors reported that MSC-derived exosomes were enriched in miR-100 and were able to suppress angiogenesis in vitro, down-regulating VEGF expression through the modulation of the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor 1-alpha (HIF-1α)/VEGF signaling in breast cancer cells [50]. Here, HIF1A is linked to breast carcinoma.