Recently, Wang and coworkers reported that CAF-derived exosomes carrying miR-181d-5p function as promoters in the EMT, invasion and migration of MCF-7 breast cancer cells, reducing the expression of Caudal-related homeobox 2 (CDX2) and homeobox A5 (HOXA5) [39]. This evidence concerns the gene HOXA5 and breast carcinoma.