This phase I-II study included 39 patients with metastatic NSCLC who received four cycles of ipilimumab in combination with a SABR regime of 28.5 Gy in 3 fx or 30 Gy in 5 fx (based on the fractionation that showed synergy with anti-CTLA-4 in preclinical studies). Here, CTLA4 is linked to non-small cell lung carcinoma.