Most of these genes are involved in signal transduction in cancer (MAPK pathway, TGF-β, p53 and NF-ƙB pathways); apoptosis and peroxisome and mitochondrial metabolisms (Supplementary Figure S2A and Supplementary Table S2 List of genes differentially expressed in Morrbid ASO KD). The gene discussed is TGFB1; the disease is cancer.