D. discoideum exhibits several members of the Ras GTPases enzymes, belonging to 14 Ras family genes with 5 characterized isoforms which share similarities with mammalian H-Ras (proto-oncogene involved in the development of several types of cancer) and K-Ras (proto-oncogene involved in the Warburg effect of cancer cells) [23]. Here, HRAS is linked to cancer.