We can, therefore, speculate that one contributing factor to schizophrenia development might be the hypermethylation of RELN (involved in axonic and dendritic extension, and neuronal migration), which reduces its expression in the brain, whereas the hypomethylation of the MB-COMT gene may increase the level of its product in the brain and stimulate positive symptoms. Here, COMT is linked to schizophrenia.