A whole-genome methylation study on the frontal cortex from 35 schizophrenia cases and 35 healthy controls reported schizophrenia-associated differences in DNA methylation in a plethora of loci, including many genes functionally related to disease etiology, such as the glutamate-receptor genes NR3B (GRIN3B) and GRIA2, hypo-methylated specifically in male patients, and also genes involved in GABAergic neurotransmission pathways, such as MARLIN-1 (JAKMIP1) and KCNJ6, which are hyper-methylated in females and males, respectively [31]. This evidence concerns the gene GRIA2 and schizophrenia.