Since alpha 1-adrenoceptor antagonists have been reported to induce autophagy in prostate cancer cells [30,31] and autophagy plays a role in resistance against EGFR-TKI [15,16,17,18], we examined if osimertinib and doxazosin induced autophagy in cancer cells and CSCs. The gene discussed is EGFR; the disease is prostate cancer.