The stabilized HIF1α can be transported into the nucleus and forms a heterodimer with HIF1β, which then recruits p300/CBP to form an active complex that binds to the hypoxia-responsive element (HRE) in the promoter region of genes encoding glycolytic enzymes, including aldolase A, enolase 1, lactate dehydrogenase A (LDHA), phosphofructokinase, phosphoglycerate kinase, pyruvate kinase, and glucose transporters [166], promoting glucose breakdown to provide building blocks necessary for cancer cell proliferation. The gene discussed is HIF1A; the disease is cancer.