Oxidative stress (Nitro-Tyr) (Figure 4C), MCP-1 (Figure 4D) and F4/80 (Figure 4C,E) in epididymal adipose tissue were significantly increased in the CKD mice, and these increases were suppressed by the administration of AST-120 (Figure 4C–E). The gene discussed is CCL2; the disease is chronic kidney disease.