OGG1 and pulmonary fibrosis: MtOGG1 may be of particular interest given that mtOGG1 prevents oxidant-induced AEC apoptosis by mitigating mtDNA damage [7,8,49] and that asbestos- and bleomycin-induced lung fibrosis is increased in Ogg1-/- mice but reduced in mice globally overexpressing the human mitochondria-targeted OGG1 subunit 1-alpha transgene (mtOgg1tg) with concordant changes in AT2 cell mtDNA damage and apoptosis [29,31].