Accumulating evidence has firmly established a prominent role for SPHK1/ S1P signaling in the pathobiology of IPF and murine lung fibrosis but the detailed molecular mechanisms involved are not fully understood, nor whether blocking SPHK1 activation following exposure to fibrogenic agents is protective [3,4,15,20,21,39,40]. This evidence concerns the gene SPHK1 and pulmonary fibrosis.