Trpa1 and Trpv1 gene deletion decreased dextran sulfate sodium (DSS)-induced colitis severity [24], as well as Il10−/−-induced spontaneous colitis in Trpv1-deficient mice [21], whereas Trpv1-deficient mice exhibited more severe colitis in the dinitrobenzene sulfonic acid (DNBS)-induced model [25]. This evidence concerns the gene IL10 and colitis.