Besides, it has been shown that soluble human CD155, that binds with higher affinity to DNAM-1 than to TIGIT and CD96, affects DNAM-1-mediated NK cell degranulation in vitro and, in a mouse model, interferes with the DNAM-1-mediated cytotoxic activity of NK cells, and promotes murine melanoma progression [35]. Here, CD226 is linked to melanoma.