Although we have not found statistically significant relationships between the expression of DNAM-1, TIGIT and TACTILE on NK or T cells with markers of poor prognosis such as the cytogenetic risk, the analysis of the NK and T cell subsets defined by the co-expression of DNAM-1, TIGIT and TACTILE shows that the expansion of the DNAM-1−TIGIT+TACTILE+ T cell subset is associated with lower survival in AML patients. The gene discussed is CD226; the disease is acute myeloid leukemia.