The analysis of DNAM-1, TIGIT and TACTILE demonstrating a different pattern of expression in NK and T cell subsets supports that the regulation of this axis of activating and inhibitory receptors that recognize proteins of the Nectin and Nectin-like families, frequently overexpressed in cancer, represents a new strategy to overcome tumor-induced suppression of both NK and T cells. The gene discussed is NECTIN1; the disease is neoplasm.