Specifically, DNAM-1+TIGIT−TACTILE− cells (p = 0.023) were reduced in AML patients, while DNAM-1−TIGIT+TACTILE+ cells (p = 0.014) and DNAM-1− TIGIT+TACTILE− cells (p = 0.01) were increased (Figure 5a, middle row and Figure 6b). The gene discussed is CD226; the disease is acute myeloid leukemia.