The effects of TIGIT blockade in non-small-cell lung cancer in combination with anti-PD-L1 mAbs (NCT04294810; NCT04256421) and in advanced metastatic solid tumors in combination with anti-PD-1 mAbs (NCT03119428; NCT04047862) are being analyzed. The gene discussed is TIGIT; the disease is non-small cell lung carcinoma.